Špela Knez (Avtor), Mojca Narat (Avtor), Jernej Ogorevc (Avtor)

Povzetek

Toll-like receptors (TLRs) play an important role in the recognition of viral particles and activation of the innate immune system, but their role in SARS-CoV-2 infection is still poorly characterized. In the present study, we investigated the role of Toll-like receptor 10 (TLR10) in modulating the immune response during SARS-CoV-2 infection. The results showed that overexpression of TLR10 in A549 lung epithelial cells, immunostimulated with SARS-CoV-2 proteins S and N mainly downregulated proinflammatory cytokines and interferons and affected gene expression in the cocultured THP-1 monocytes. Our results suggest that TLR10 could mediate the extent of SARS-CoV-2 infection by downregulating the release of inflammatory cytokines and chemokines such as CXCL10, IL6, IL8, and IFNβ. Modulation of TLR10 expression could have implications for the treatment of patients with severe COVID-19, in whom excessive inflammation leading to the development of acute respiratory distress syndrome (ARDS) is a key feature. However, further research is needed to fully understand the impact of modulating TLR10 expression on the antiviral response and the overall balance of the immune response during SARS-CoV-2 infection.

Ključne besede

imunologija;pljuča;epitelne celice;vnetje;TLR10;COVID-19;SARS-CoV-2;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL BF - Biotehniška fakulteta
UDK: 577.27
COBISS: 223003139 Povezava se bo odprla v novem oknu
ISSN: 1664-3224
Št. ogledov: 29
Št. prenosov: 1
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: imunologija;pljuča;epitelne celice;vnetje;TLR10;COVID-19;SARS-CoV-2;
Vrsta dela (COBISS): Članek v reviji
Strani: 11 str.
Letnik: ǂVol. ǂ15
Zvezek: [article. no.] 1490478
Čas izdaje: 2025
DOI: 10.3389/fimmu.2024.1490478
ID: 25814597