Patricija Lunar (Avtor), Hana Meglič (Avtor), Mateja Vehar (Avtor), Sabina Ugovšek (Avtor), Andreja Rehberger Likozar (Avtor), Miran Šebeštjen (Avtor), Janja Zupan (Avtor)

Povzetek

Background: PCSK9 inhibitors (PCSK9i) represent a newer form of atherosclerosis treatment. Inflammation and haemostasis are key processes in the development of atherosclerosis. In this study, we investigated the influence of therapy with PCSK9i in patients with coronary artery disease (CAD) on regulators for lipoprotein homeostasis, inflammation and coagulation. Methods: Using quantitative polymerase chain reaction (qPCR), we measured the expression of the genes involved in lipoprotein homeostasis, namely for sterol regulatory element-binding protein 1 (SREBP1), SREBP2, low-density lipoprotein receptor (LDLR), hepatic lipase type C (LIPC), LDLR-related protein 8 (LRP8), and the genes associated with inflammation and coagulation, such as cluster of differentiation (CD) 36 (CD36), CD63, and CD14 in 96 patients with CAD and 25 healthy subjects. Results: Significant differences in the expression of the investigated genes between patients and healthy controls were found. Treatment with PCSK9i also resulted in significant changes in the expression of all studied genes. Conclusions: We established that PCSK9i may have a significant effect on the gene expression of lipid regulators, inflammatory markers, and coagulation parameters, independent of their lipolytic effect.

Ključne besede

PCSK9 inhibitors;lipid regulators;inflammation;coagulation;coronary artery disease;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FFA - Fakulteta za farmacijo
UDK: 616-002:616.132.2
COBISS: 224843267 Povezava se bo odprla v novem oknu
ISSN: 2227-9059
Št. ogledov: 27
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: zaviralci PCSK9;regulatorji lipidov;koagulacija;bolezen koronarnih arterij;Vnetje;Koronarne arterije;
Vrsta dela (COBISS): Članek v reviji
Strani: 15 str.
Letnik: ǂVol. ǂ13
Zvezek: ǂissue ǂ2, [article no.] 294
Čas izdaje: 2025
DOI: 10.3390/biomedicines13020294
ID: 25847391