Taja Zore (Avtor), Jasna Lojk (Avtor), Katarina Reberšek (Avtor), Elizabeta Božnar Alič (Avtor), Urška Čegovnik (Avtor), Alenka France Štiglic (Avtor), Tatjana Lejko-Zupanc (Avtor), Janja Marc (Avtor), Darko Černe (Avtor), Aleš Jerin (Avtor), Irena Prodan Žitnik (Avtor), Helena Podgornik (Avtor), Nada Snoj (Avtor), Barbara Ostanek (Avtor), Gabriele Turel (Avtor)

Povzetek

Objectives: Despite extensive study of COVID-19 disease, only a few studies also addressed the aftermath of the disease and potential long-term consequences. The aim of this study was to assess COVID-19 resolution through the cross-sectional analysis of an extensive range of haematological and biochemical laboratory parameters and to find potential markers still associated with disease severity 5-6-months post infection. Methods: In this study, we analysed 92 routine biochemical, haematological and immunological parameters in 75 non-vaccinated patients 5–6 months after recorded first time SARS-CoV-2 infection without reinfection. Demographic and disease severity data were obtained through surveys. Results: The majority of analysed parameters were within the normal reference intervals, however, statistically significant correlations with the disease severity were detected in 15 parameters: B lymphocytes, NK cells, interleukin (IL)-12, IL-1β, cortisol, ferritin, SARS-CoV-2 specific IgG and IgM antibodies, Na, Cl, creatinine, alkaline phosphatase, cholesterol, HbA1c and alpha 2 and beta 2 globulin fractions of the proteinogram. Conclusions: Although most observed parameters returned to their normal reference intervals, significant correlations were still observed with disease severity, that could indicate either the pre-infection baseline state which affected disease outcome or minor remaining alterations in function of certain organs, pertaining their stress or damage during the acute phase of the disease.

Ključne besede

disease severity;laboratory parameters;resolution;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FFA - Fakulteta za farmacijo
UDK: 542:616.98:578.834
COBISS: 232905475 Povezava se bo odprla v novem oknu
ISSN: 2405-8440
Št. ogledov: 70
Št. prenosov: 24
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: resnost bolezni;laboratorijski parametri;resolucija;COVID-19;SARS-CoV-2;Laboratorijska kemija;Laboratorijska medicina;
Vrsta dela (COBISS): Članek v reviji
Strani: 12 str.
Letnik: ǂVol. ǂ11
Zvezek: ǂiss. ǂ4, [article no.] e42535
Čas izdaje: Feb. 2025
DOI: 10.1016/j.heliyon.2025.e42535
ID: 26225417