preference for Watson–Crick pairing over homobase interactions in DNA
Carmen López-Chamorro (Avtor), Antonio Pérez-Romero (Avtor), Alicia Domínguez-Martín (Avtor), Uroš Javornik (Avtor), Oscar Palacios (Avtor), Janez Plavec (Avtor), Miguel A. Galindo (Avtor)

Povzetek

DNA strands modified with 7-deazaadenine (X) and 7-deazaguanine (Y) have shown promise in forming silver-DNA assemblies while maintaining canonical Watson–Crick base pairing, highlighting the compatibility of silver binding with standard DNA structures. However, critical questions remain regarding the binding preferences of AgI ions to sequences containing 7-deazapurine bases, particularly the prevalence of silver-modified Watson–Crick base pairs versus alternative homobase pair arrangements. To address this, we examined the binding of AgI to complementary X-T sequences, demonstrating a strong preference for canonical X-AgI-T pairing over homoleptic X-AgI-X or T-AgI-T pairs. Additionally, we report the discovery of a novel metallized DNA duplex featuring continuous X-AgI-X homobase pairs, whose structural analysis at the monomeric level, using model base 9-propyl-7-deazaadenine (pX) and AgI salts, reveals a unique silver-binding pattern through the Watson–Crick face. These findings not only advance our understanding of silver-mediated DNA architectures using 7-deazapurines but also provide a foundation for the rational design of sophisticated metal-DNA nanostructures with tailored properties, opening new avenues for the development of functional DNA-based materials.

Ključne besede

anorganska kemija;DNA;nanostrukture;lastnosti;crystal structure;genetics;ions;silver;solution chemistry;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: KI - Kemijski inštitut
UDK: 54
COBISS: 247846147 Povezava se bo odprla v novem oknu
ISSN: 1520-510X
Št. ogledov: 267
Št. prenosov: 112
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: anorganska kemija;DNA;nanostrukture;lastnosti;
Komentar vira: Nasl. z nasl. zaslona; Soavtorja iz Slovenije: Uroš Javornik, Janez Plavec; Opis vira z dne 5. 9. 2025;
Strani: str. 14455–14465
Letnik: ǂVol. ǂ64
Zvezek: ǂiss. ǂ28
Čas izdaje: 10. Jul. 2025
DOI: 10.1021/acs.inorgchem.5c01762
ID: 27266833