Matjaž Perc (Avtor), Anne K. Green (Avtor), C. Jane Dixon (Avtor), Marko Marhl (Avtor)

Povzetek

Calcium has been established as a key messenger in both intra- and intercellular signaling. Experimentally observed intracellular calcium responses to different agonists show a variety of behaviors from simple spiking to complex oscillatory regimes. Here we study typical experimental traces of calcium oscillations in hepatocytes obtained in response to phenylephrine and ATP. The traces were analyzed with methods of nonlinear time series analysis in order to determine the stochastic/deterministic nature of the intracellular calcium oscillations. Despite the fact that the oscillations appear, visually, to be deterministic yet perturbed by noise, our analyses provide strong evidence that the measured calcium traces in hepatocytes are prevalently of stochastic nature. In particular, bursting calcium oscillations are temporally correlated Gaussian series distorted by a monotonic, instantaneous, time-independent function, whilst the spiking behavior appears to have a dynamical nonlinear component whereby the overall determinism level is still low. The biological importance of this finding is discussed in relation to the mechanisms incorporated in mathematical models as well as the role of stochasticity and determinism at cellular and tissue levels which resemble typical statistical and thermodynamic effects in physics.

Ključne besede

dinamični sistemi;stohastični procesi;celični sistemi;kalcijeve oscilacije;analize časovnih zaporedij;hrup;časovne korelacije;dynamic systems;stochastic processes;cellular signaling;calcium oscillations;time series analyses;noise;temporal correlation;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UM FNM - Fakulteta za naravoslovje in matematiko
UDK: 539.2:519.216
COBISS: 15744008 Povezava se bo odprla v novem oknu
ISSN: 0301-4622
Št. ogledov: 1400
Št. prenosov: 114
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Angleški jezik
Sekundarne ključne besede: dinamični sistemi;stohastični procesi;celični sistemi;kalcijeve oscilacije;analize časovnih zaporedij;hrup;časovne korelacije;
URN: URN:SI:UM:
Strani: str. 33-38
Letnik: ǂVol. ǂ132
Zvezek: ǂiss. ǂ1
Čas izdaje: 2008
ID: 8724010