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Št. zadetkov: 2
Vpliv izbranih prostih in v nanodelce vgrajenih antagonistov nikotinskih acetilholinskih receptorjev na celice raka pljuč
Ahmad Joukhan, Damjana Drobne, Marija Sollner Dolenc
Doktorska disertacija
Oznake: marine toxins;nicotinic acetylcholine receptors;nAChR antagonists;3-alkylpyridinium salts;chemotherapeutic agents;
The overexpression of nicotinic acetylcholine receptors (nAChRs), particularly ?7-nAChR, in lung cancer cells facilitates the binding of nicotine or other nAChR agonists such as nicotine metabolites or acetylcholine. The binding and activation of these receptors not only promote tumor growth but als ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Attenuation of Nicotine Effects on A549 Lung Cancer Cells by Synthetic α7 nAChR Antagonists APS7-2 and APS8-2
Ahmad Joukhan, Veno Kononenko, Tadeja Bele, Marija Sollner Dolenc, Steve Peigneur, Ernesto Lopes Pinheiro-Junior, Jan Tytgat, Tom Turk, Igor Križaj, Damjana Drobne
Izvirni znanstveni članek
Oznake: marine toxin;nicotinic acetylcholine receptor;nAChR antagonist;APS7-2;APS8-2;
Nicotine binds to nicotinic acetylcholine receptors (nAChRs) that are overexpressed in different cancer cells, promoting tumor growth and resistance to chemotherapy. In this study, we aimed to investigate the potential of APS7-2 and APS8-2, synthetic analogs of a marine sponge toxin, to inhibit nico ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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