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Immunosuppressive effects of new thiophene-based Kv1.3 inhibitors
Špela Gubič, Alberto Montalbano, Cesare Sala, Andrea Becchetti, Louise Antonia Hendrickx, Kenny M. Van Theemsche, Ernesto Lopes Pinheiro-Junior, Janez Ilaš, Tihomir Tomašić, Lucija Peterlin-Mašič
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Oznake: inhibitorji;ionski kanal KV1.3;T-limfocitni imunosupresiv;ion channel;KV1.3 inhibitor;T-lymphocyte;immunosuppressive;
Voltage-gated potassium channel KV1.3 inhibitors have been shown to be effective in preventing T-cell proliferation and activation by affecting intracellular Ca2+ homeostasis. Here, we present the structure-activity relationship, KV1.3 inhibition, and immunosuppressive effects of new thiophene-based ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
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