Iskalni niz:
išči po
išči po
išči po
išči po
Vrsta gradiva:
Jezik:
Št. zadetkov: 8
Astrocytic pathological calcium homeostasis and impaired vesicle trafficking in neurodegeneration
Nina Vardjan, Alexei Verkhratsky, Robert Zorec
Pregledni znanstveni članek
Oznake: Alzheimerjeva bolezen;Parkinsonova bolezen;nevrodegeneracija;Alzheimer's disease;Parkinson's disease;neurodegeneration;
Although the central nervous system (CNS) consists of highly heterogeneous populations of neurones and glial cells, clustered into diverse anatomical regions with specific functions, there are some conditions, including alertness, awareness and attention that require simultaneous, coordinated and sp ...
Leto: 2017 Vir: Medicinska fakulteta (UL MF)
Pre-and postfusion tuning of regulated exocytosis by cell metabolites
Robert Zorec, Robert Zorec, Alexei Verkhratsky
Kratki znanstveni prispevek
Oznake: regulated exocytosis;fusion pore;vesicle cholesterol;
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19
Luca Steardo, Luca Steardo, Robert Zorec, Alexei Verkhratsky
Pregledni znanstveni članek
Oznake: nevroinfekcija;patofiziologija;klinične manifestacije;covid-19;neuronfection;pathophysiology;clinical manifestations;
Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Exocytosis of large-diameter lysosomes mediates interferon [gamma]-induced relocation of MHC class II molecules toward the surface of astrocytes
Mićo Božić, Alexei Verkhratsky, Robert Zorec, Matjaž Stenovec
Izvirni znanstveni članek
Oznake: astroglia;inflammatory cytokines;fusion pore;adaptive immunity;patch clamp;lysosomes;
Astrocytes are the key homeostatic cells in the central nervous system; initiation of reactive astrogliosis contributes to neuroinflammation. Pro-inflammatory cytokine interferon [gamma] (IFN[gamma]) induces the expression of the major histocompatibility complex class II (MHCII) molecules, involved ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Astrocytes in rapid ketamine antidepressant action
Matjaž Stenovec, Baoman Li, Alexei Verkhratsky, Robert Zorec
Pregledni znanstveni članek
Oznake: astroglia;ketamine;exocytosis;
Ketamine, a general anaesthetic and psychotomimetic drug, exerts rapid, potent and long-lasting antidepressant effect, albeit the cellular and molecular mechanisms of this action are yet to be discovered. Besides targeting neuronal NMDARs fundamental for synaptic transmission, ketamine affects the f ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Astrocyte specific remodeling of plasmalemmal cholesterol composition by ketamine indicates a new mechanism of antidepressant action
Eva Lasič, Marjeta Lisjak, Anemari Horvat, Mićo Božić, Aleksandra Šakanović, Gregor Anderluh, Alexei Verkhratsky, Nina Vardjan, Jernej Jorgačevski, Matjaž Stenovec, Robert Zorec
Izvirni znanstveni članek
Oznake: astrocytes;ketamine;cholesterol;
Ketamine is an antidepressant with rapid therapeutic onset and long-lasting effect, although the underlying mechanism(s) remain unknown. Using FRET-based nanosensors we found that ketamine increases [cAMP]i in astrocytes. Membrane capacitance recordings, however, reveal fundamentally distinct mechan ...
Leto: 2019 Vir: Medicinska fakulteta (UL MF)
Astrocyte arborization enhances Ca[sup]2+ but not cAMP signaling plasticity
Samo Pirnat, Mićo Božić, Dorian Dolanc, Anemari Horvat, Petra Tavčar Verdev, Nina Vardjan, Alexei Verkhratsky, Robert Zorec, Robert Zorec, Matjaž Stenovec, Matjaž Stenovec
Izvirni znanstveni članek
Oznake: astrocytes;vesicles;confocal microscopy;
The plasticity of astrocytes is fundamental for their principal function, maintaining homeostasis of the central nervous system throughout life, and is associated with diverse exposomal challenges. Here, we used cultured astrocytes to investigate at subcellular level basic cell processes under contr ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Vesicle cholesterol controls exocytotic fusion pore
Boštjan Rituper, Alenka Guček, Marjeta Lisjak, Urszula Górska, Aleksandra Šakanović, Saša Trkov, Eva Lasič, Mićo Božić, Jernej Jorgačevski, Marko Kreft, Alexei Verkhratsky, Gregor Anderluh, Matjaž Stenovec, Bojan Božič, Robert Zorec, Robert Zorec
Izvirni znanstveni članek
Oznake: cholesterol;exocytosis;fusion pore conductance;
In some lysosomal storage diseases (LSD) cholesterol accumulates in vesicles. Whether increased vesicle cholesterol affects vesicle fusion with the plasmalemma, where the fusion pore, a channel between the vesicle lumen and the extracellular space, is formed, is unknown. Super-resolution microscopy ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 8
Ključne besede:
Leto izdaje:
Avtorji:
Repozitorij:
Tipologija:
Jezik: