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Št. zadetkov: 4
Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?
Amaya Azqueta, Helga Stopper, Bojana Žegura, Maria Dusinska, Peter Møller
Izvirni znanstveni članek
Oznake: test komet;citotoksičnost;genotoksičnost;poškodbe DNK;celična smrt;comet assay;cytotoxicity;genotoxicity;DNA damage;cell death;
The comet assay is used to measure DNA damage induced by chemical and physical agents. High concentrations of test agents may cause cytotoxicity or cell death, which may give rise to false positive results in the comet assay. Systematic studies on genotoxins and cytotoxins (i.e. non-genotoxic poison ...
Leto: 2022 Vir: Nacionalni inštitut za biologijo (NIB)
New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens
Marc Audebert, Ann-Sophie Assmann, Amaya Azqueta, Pavel Babica, Emilio Benfenati, Martina Štampar, Bojana Žegura
Pregledni znanstveni članek
Oznake: negenotoksični karcinogeni;metodologije novih pristopov;ocena nevarnosti;način delovanja;toksikologija;biokemija;non-genotoxic carcinogens;NGTxC;new approach methodologies;NAM;PARC;
Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcinogens (NGTxCs). Genotoxic compounds induce DNA damage, which can be detected by an established in vitro and in vivo battery of genotoxicity assays. For NGTxCs, DNA is not the primary target, and the p ...
Leto: 2023 Vir: Nacionalni inštitut za biologijo (NIB)
Minimum Information for Reporting on the Comet Assay (MIRCA)
Peter Møller, Amaya Azqueta, Elisa Boutet-Robinet, Gudrun Koppen, Stefano Bonassi, Mirta Milić, Goran Gajski, Solange Costa, Bojana Žegura, Matjaž Novak
Izvirni znanstveni članek
Oznake: Komet test;genotoksičnost;DNA poškodbe;
The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental systems. These differences may be attributed to protocol differences, although it is di ...
Leto: 2020 Vir: Nacionalni inštitut za biologijo (NIB)
DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
Stefano Bonassi, Marcello Ceppi, Peter Møller, Amaya Azqueta, Mirta Milić, Gunnar Brunborg, Gudrun Koppen, Marco Bruzzone, Juliana Da Silva, Danieli Benedetti, Silvia Moretti, Patrizia Riso, Patrizia Russo, Ricardo Marcos, Goran Gajski, Biljana Spremo-Potparević, Lada Živković, Elisa Boutet-Robinet, Maria Dusinska, Andrew Collins, Bojana Žegura
Izvirni znanstveni članek
Oznake: biokemija;poškodbe DNK;levkociti;testiranje;
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy ...
Leto: 2021 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 4
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