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Control compounds for preclinical drug-induced liver injury assessment
Antonio Segovia-Zafra, Marina Villanueva-Paz, Ana Sofia Serras, Gonzalo Matilla-Cabello, Ana Bodoque-Garcia, Daniel E. Di Zeo-Sánchez, Hao Niu, Ismael Alvarez-Alvarez, Laura Sanz-Villanueva, Sergej Godec, Irina Milisav
Izvirni znanstveni članek
Oznake: clinical data;control compounds;drug-induced liver injury;expert committee;panel of control drugs;preclinical drug safety testing;validation of in vitro DILI models;
Background & aims: Idiosyncratic drug-induced liver injury (DILI) is a complex and unpredictable event caused by drugs, and herbal or dietary supplements. Early identification of human hepatotoxicity at preclinical stages remains a major challenge, in which the selection of validated in vitro system ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
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