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Targeting oxysterol-binding protein (OSBP) as a novel strategy to inhibit herpes simplex virus 2 (HSV-2) replication
Andrea Civra, Andrea Civra, Fatima Nigro, Fatima Nigro, Domiziana Porporato, Domiziana Porporato, Matteo Costantino, Elisa Bianconi, Federico Zambri, Matteo De March, Marco De Conto, Emanuele Carosati, Antonio Macchiarulo
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Oznake: broad-spectrum antiviral;cholenamide derivatives;herpes simplex virus replication;oxysterol-binding protein (OSBP);oxysterols;
25-Hydroxycholesterol (25-HC) and 25R,26-hydroxycholesterol (25R,26-HC) are two endogenous oxysterols endowed with broad-spectrum antiviral activity. They hamper viral replication by targeting oxysterol-binding protein (OSBP), a host lipid transporter which plays a critical role in the replicative c ...
Leto: 2026 Vir: Univerza v Novi Gorici (UNG)
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