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Št. zadetkov: 6
Ca[sup]2+ as the prime trigger of aerobic glycolysis in astrocytes
Anemari Horvat, Marko Muhič, Tina Smolič, Ena Begić, Robert Zorec, Marko Kreft, Nina Vardjan
Izvirni znanstveni članek
Oznake: astrocytes;aerobic glycolysis;d-glucose;
Astroglial aerobic glycolysis, a process during which d-glucose is converted to l-lactate, a brain fuel and signal, is regulated by the plasmalemmal receptors, including adrenergic receptors (ARs) and purinergic receptors (PRs), modulating intracellular Ca2+ and cAMP signals. However, the extent to ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Astrocytes with TDP-43 inclusions exhibit reduced noradrenergic cAMP and Ca[sup]2+ signaling and dysregulated cell metabolism
Jelena Velebit Marković, Anemari Horvat, Tina Smolič, Sonja Prpar, Boris Rogelj, Robert Zorec, Nina Vardjan
Izvirni znanstveni članek
Oznake: astrociti;celična presnova;nevroni;astrocytes;cell metabolism;neurons;
Most cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have cytoplasmic inclusions of TAR DNA-binding protein 43 (TDP-43) in neurons and non-neuronal cells, including astrocytes, which metabolically support neurons with nutrients. Neuronal metabolism largely depends on t ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Astrocyte specific remodeling of plasmalemmal cholesterol composition by ketamine indicates a new mechanism of antidepressant action
Eva Lasič, Marjeta Lisjak, Anemari Horvat, Mićo Božić, Aleksandra Šakanović, Gregor Anderluh, Alexei Verkhratsky, Nina Vardjan, Jernej Jorgačevski, Matjaž Stenovec, Robert Zorec
Izvirni znanstveni članek
Oznake: astrocytes;ketamine;cholesterol;
Ketamine is an antidepressant with rapid therapeutic onset and long-lasting effect, although the underlying mechanism(s) remain unknown. Using FRET-based nanosensors we found that ketamine increases [cAMP]i in astrocytes. Membrane capacitance recordings, however, reveal fundamentally distinct mechan ...
Leto: 2019 Vir: Medicinska fakulteta (UL MF)
Astrocyte arborization enhances Ca[sup]2+ but not cAMP signaling plasticity
Samo Pirnat, Mićo Božić, Dorian Dolanc, Anemari Horvat, Petra Tavčar Verdev, Nina Vardjan, Alexei Verkhratsky, Robert Zorec, Robert Zorec, Matjaž Stenovec, Matjaž Stenovec
Izvirni znanstveni članek
Oznake: astrocytes;vesicles;confocal microscopy;
The plasticity of astrocytes is fundamental for their principal function, maintaining homeostasis of the central nervous system throughout life, and is associated with diverse exposomal challenges. Here, we used cultured astrocytes to investigate at subcellular level basic cell processes under contr ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
ǂThe ǂactivation of GPR27 increases cytosolic L-lactate in 3T3 embryonic cells and astrocytes
Dorian Dolanc, Tomaž Mark Zorec, Zala Smole, Anja Maver, Anemari Horvat, Thanigaimalai Pillaiyar, Saša Trkov, Nina Vardjan, Marko Kreft, Helena Chowdhury Haque, Robert Zorec, Robert Zorec
Izvirni znanstveni članek
Oznake: 3T3 embrionalne celice;astrociti;aerobna glikoliza;3T3 embryonic cells;astrocytes;aerobic glycolysis;
G-protein-coupled receptors (GPCRs) represent a family with over 800 members in humans, and one-third of these are targets for approved drugs. A large number of GPCRs have unknown physiologic roles. Here, we investigated GPR27, an orphan GPCR belonging to the family of super conserved receptor expre ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
Astrocytes in stress accumulate lipid droplets
Tina Smolič, Petra Tavčar Verdev, Anemari Horvat, Urška Černe, Ana Halužan Vasle, Larisa Tratnjek, Mateja Erdani-Kreft, Nicole Scholz, Maja Matis, Toni Petan, Robert Zorec, Nina Vardjan
Izvirni znanstveni članek
Oznake: astrocytes;stress stimuli;metabolism;
When the brain is in a pathological state, the content of lipid droplets (LDs), the lipid storage organelles, is increased, particularly in glial cells, but rarely in neurons. The biology and mechanisms leading to LD accumulation in astrocytes, glial cells with key homeostatic functions, are poorly ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 6
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