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Št. zadetkov: 3
IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers
Marchien G. Dallinga, Bahar Yetkin-Arik, Richelle P. Kayser, Ilse M.C. Vogels, Patrycja Nowak-Sliwinska, Arjan W. Griffioen, Cornelis J. F. van Noorden, Ingeborg Klaassen, Reinier O. Schlingemann
Izvirni znanstveni članek
Oznake: biokemija;angiogeneza;endotelne celice;CD34;IGF2;Angiogenesis;tip cells;endothelial cells;cultured cells;endothelial growth factors;
Tip cells, the leading cells of angiogenic sprouts, were identified in cultures of human umbilical vein endothelial cells (HUVECs) by using CD34 as a marker. Here, we show that tip cells are also present in primary human microvascular endothelial cells (hMVECs), a more relevant endothelial cell type ...
Leto: 2018 Vir: Nacionalni inštitut za biologijo (NIB)
Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy
Bahar Yetkin-Arik, Arnoud W. Kastelein, Ingeborg Klaassen, Charlotte H. J. R. Jansen, Yani P. Latul, Miloš Vittori, Aydan Biri, Korhan Kahraman, Arjan W. Griffioen, Frederic Amant, Christianne A. R. Lok, Reinier O. Schlingemann, Cornelis J. F. van Noorden
Pregledni znanstveni članek
Oznake: angiogeneza;antiangiogena terapija;tumorsko mikrookolje;ginekološki raki;angiogenesis;anti-angiogenic therapy;endothelial cells;endothelial cell metabolism;gynecological cancer;non-tip cells;tip cells;tumor microenvironment;vascular disrupting agents;
Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development of anti-angiogenesis therapy in gynecological cancers and improvement of its efficacy have been a major focus of fundamental and clinical research. However, sur ...
Leto: 2021 Vir: Repozitorij Univerze v Ljubljani (RUL)
New insights in ATP synthesis as therapeutic target in cancer and angiogenic ocular diseases
Cornelis J. F. van Noorden, Bahar Yetkin-Arik, Paola Serrano Martinez, Noëlle Bakker, Mathilda E. van Breest Smallenburg, Reinier O. Schlingemann, Ingeborg Klaassen, Bernarda Majc, Anamarija Habič, Urban Bogataj, Katrin S. Galun, Miloš Vittori, Mateja Erdani-Kreft, Metka Novak, Barbara Breznik, Vashendriya V. V. Hira
Pregledni znanstveni članek
Oznake: aerobic glycolysis;anaerobic glycolysis;angiogenesis;ATP synthesis;cancer cells;cancer stem cells;endothelial cells;energy metabolism;eye diseases;oxidative phosphorylation;pericytes;retina;Warburg effect;
Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and ...
Leto: 2024 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 3
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