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Št. zadetkov: 3
Design, synthesis, and biological evaluation of 2-(benzylamino-2-hydroxyalkyl)isoindoline-1,3-diones derivatives as potential disease-modifying multifunctional anti-Alzheimer agents
Dawid Panek, Anna Więckowska, Anna Pasieka, Justyna Godyń, Jakub Jończyk, Marek Bajda, Damijan Knez, Stanislav Gobec, Barbara Malawska
Izvirni znanstveni članek
Oznake: isoindoline-1,3-dione derivatives;cholinesterase inhibitors;BACE-1 inhibitors;Abeta-aggregation;molecular modeling;multiple anti-Alzheimer's ligands;
The complex nature of Alzheimer's disease calls for multidirectional treatment. Consequently, the search for multi-target-directed ligands may lead to potential drug candidates. The aim of the present study is to seek multifunctional compounds with expected activity against disease-modifying and sym ...
Leto: 2018 Vir: Fakulteta za farmacijo (UL FFA)
Synthesis, molecular modelling and biological evaluation of novel heterodimeric, multiple ligands targeting cholinesterases and amyloid beta
Michalina Hebda, Marek Bajda, Anna Więckowska, Natalia Szałaj, Anna Pasieka, Dawid Panek, Justyna Godyń, Tomasz Wichur, Damijan Knez, Stanislav Gobec, Barbara Malawska
Izvirni znanstveni članek
Oznake: tarčna zdravila;razvoj zdravil;zaviralci acetilholinesteraze;molekularno modeliranje;
Cholinesterases and amyloid beta are one of the major biological targets in the search for a new and efficacious treatment of Alzheimer's disease. The study describes synthesis and pharmacological evaluation of new compounds designed as dual binding site acetylcholinesterase inhibitors. Among the sy ...
Leto: 2016 Vir: Fakulteta za farmacijo (UL FFA)
Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer's disease
Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Izvirni znanstveni članek
Oznake: Alzheimer's disease;quinazolinones;multicomponent reactions;multitarget-directed ligands;antioxidants;cholinesterase inhibitors;hepatotoxicity;
We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (I ...
Leto: 2016 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 3
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