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Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes
Blaž Kociper, Nives Škorja, Ivana Ogrizek, Katarina Miš, Sergej Pirkmajer, Sergej Pirkmajer
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Oznake: chloroquine;hypoxia-inducible factor-1α (HIF-1α);MG132;myotubes;PYR-41;pyruvate dehydrogenase kinase 1 (PDK1);
Pyruvate dehydrogenase kinase (PDK), which phosphorylates the pyruvate dehydrogenase complex, regulates glucose metabolism in skeletal muscle. PDK1, an isozyme whose expression is controlled by hypoxia-inducible factor-1α (HIF-1α), is thought to play a role in muscle adaptation to hypoxia. While tra ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
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