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Allosteric coupling between transmembrane segment 4 and the selectivity filter of TALK1 potassium channels regulates their gating by extracellular pH
Wen-Hao Tsai, Cédric Grauffel, Yueh-Ming Huang, Sandra Postić, Marjan Rupnik, Carmay Lim, Shi-Bing Yang
Izvirni znanstveni članek
Oznake: potassium channel;molecular dynamics;molecular modeling;structural model;K2P;TALK1;pH sensing;C-type gate;channel activation;
Opening of two-pore domain K+ channels (K2Ps) is regulated by various external cues, such as pH, membrane tension, or temperature, which allosterically modulate the selectivity filter (SF) gate. However, how these cues cause conformational changes in the SF of some K2P channels remains unclear. Here ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 1
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