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Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i
Makoto Harada, Jonathan Adam, Marcela Covic, Jianhong Ge, Stefan Brandmaier, Caroline Muschet, Jerzy Adamski
Izvirni znanstveni članek
Oznake: anaplerosis;metabolic dysfunction-associated steatotic liver disease (MASLD);anti-inflammatory effects;metformin;pharmacometabolomics;SGLT2 inhibitors;TCA cycle;type 2 diabetes;
Background: Metformin and sodium-glucose-cotransporter-2 inhibitors (SGLT2i) are cornerstone therapies for managing hyperglycemia in diabetes. However, their detailed impacts on metabolic processes, particularly within the citric acid (TCA) cycle and its anaplerotic pathways, remain unclear. This st ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
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