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Št. zadetkov: 2
Wide-antimicrobial spectrum of picolinium salts
Sarka Salajkova, Marketa Benkova, Jan Marek, Radek Sleha, Lukas Prchal, David Malinak, Rafael Dolezal, Kristina Sepčić, Nina Gunde-Cimerman, Kamil Kuca, Ondrej Soukup
Izvirni znanstveni članek
Oznake: pikolinijeve soli;kvartarne amonijeve spojine;surfaktant;kritična micelarna koncentracija;protimikrobna aktivnost;citotoksičnost;picolinium salts;quaternary ammonium compounds;surfactant;critical micellar concentration;antimicrobial activity;cytotoxicity;
Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C$_{12}$, C$_{14}$, C$_{16}$) were p ...
Leto: 2020 Vir: Biotehniška fakulteta (UL BF)
Dual Inhibitors of p38α mitogen-activated protein kinase and butyrylcholinesterase for the modulation of neuroinflammation and cognitive dysfunction
Damijan Knez, David Malinak, Anže Meden, Svit Ferjančič Benetik, Anja Pišlar, Zuzana Kohoutova, Iveta Vondrackova, Miroslav Psotka, Antonín Lyčka, Stanislav Gobec, Stanislav Gobec
Izvirni znanstveni članek
Oznake: Inflammation;inhibitors;peptides and proteins;nervous system diseases;rodent models;
Chronic neuroinflammation and cholinergic dysfunction are major contributors to cognitive decline in Alzheimer’s disease. Here, we report a series of pyridazine-based multitarget-directed ligands that simultaneously inhibit human butyrylcholinesterase (hBChE) and p38α mitogen-activated protein kinas ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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