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Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients
Dealba Gheduzzi, Federica Boraldi, Giulia Annovi, Chiara Paolinelli DeVincenzi, Leon J. Schurgers, Cees Vermeer, Daniela Quaglino, Ivonne Pasquali Ronchetti
Izvirni znanstveni članek
Oznake: calcification;dermal fibroblast;elastic fiber;human skin;MGP;pseudoxanthoma elasticum;
Mature MGP (Matrix g-carboxyglutamic acid protein) is known to inhibit soft connective tissues calcification. We investigated its possible involvement in pseudoxanthoma elasticum (PXE), a genetic disorder whose clinical manifestations are due to mineralization of elastic fibers. PXE patients have ...
Leto: 2007 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
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