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A gene regulatory network, where two genes are connected if they are directly, or functionally, regulating each other, can be 'reverse-engineered' from large-scale experimental data such as gene expression profiles. Here used a simple but effective reverse-engineering approach using all the availabl ...

A cell can be described as a synergistic ensemble of biological entities (mRNA, proteins, ncRNA, metabolites, etc) interacting with each other, whose collective behaviour causes the observed phenotypes. A great research effort is ongoing in identifying and mapping the network of interactions among b ...