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Abl kinase-mediated FUS Tyr526 phosphorylation alters nucleocytoplasmic FUS localization in FTLD-FUS
Helena Motaln, Urša Čerček, Alfred Yamoah, Priyanka Tripathi, Eleonora Aronica, Anand Goswami, Boris Rogelj
Izvirni znanstveni članek
Oznake: FUS;phosphorylation;cytoplasmic aggregates;c-Src;c-Abl;FTLD;
Nuclear to cytoplasmic mislocalization and aggregation of multiple RNA-binding proteins (RBPs), including FUS, are the main neuropathological features of the majority of cases of amyotrophic lateral sclerosis (ALS) and frontotemporal lobular degeneration (FTLD). In ALS-FUS, these aggregates arise fr ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 1
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