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Št. zadetkov: 5
Development of chimeric innate immune agonists as vaccine adjuvants
Emiliano Paradiso, Žiga Jakopin
Raziskovalni podatki
Oznake: vaccine adjuvants;PRRs;CD1d;conjugates;α-GalCer;
This data set comprises the research data collected during doctoral studies at the Faculty of Pharmacy, University of Ljubljana, between 2022 and 2026, underpinning the doctoral dissertation "Development of chimeric innate immune agonists as vaccine adjuvants". It covers the design, synthesis, analy ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Razvoj himernih agonistov prirojenega imunskega sistema kot adjuvansov za cepiva
Emiliano Paradiso, Žiga Jakopin
Doktorska disertacija
Oznake: vaccine adjuvants;PRRs;CD1d;conjugates;α-GalCer;
Sodobna cepiva izkazujejo omejeno imunogenost, zato za sprožitev močnega in dolgotrajnega imunskega odziva potrebujejo adjuvanse. Ti delujejo tako, da spodbudijo prirojeni imunski sistem prek receptorjev za prepoznavo vzorcev (PRR), med katere spadajo Toll-u podobni receptorji (TLR), NOD-u podobni r ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Beyond α-GalCer
Emiliano Paradiso, Žiga Jakopin
Pregledni znanstveni članek
Oznake: cancer;ligands;lipids;peptides;proteins vaccination;
CD1d-restricted glycolipids have emerged as a cornerstone in the development of next-generation immunotherapies. This perspective provides a comprehensive update on structure–activity relationships, specifically examining how modifications of the prototypical CD1d ligand α-galactosylceramide (α-GalC ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Modulating receptor activity, immune response, and kinetic solubility
Emiliano Paradiso, Špela Bizjak, Žiga Jakopin
Izvirni znanstveni članek
Oznake: agonists;conjugate acid-base pairs;ethyl groups;mixtures;solubility;
Novel immunopotentiators are essential for advancing our understanding of immune receptor crosstalk and for addressing infectious diseases. Previous studies have suggested that coactivation of nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and Toll-like receptor 4 (TLR4) can s ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Conjugated NOD1-centered dual agonists exhibit modest In vitro immunomodulation but potent in vivo adjuvanticity
Emiliano Paradiso, Špela Bizjak, Veronika Klančič, Ruža Frkanec, Žiga Jakopin, Žiga Jakopin
Izvirni znanstveni članek
Oznake: NOD1;pattern recognition receptor agonists;conjugates;immunomodulator;adjuvant;
Immunomodulators that simultaneously engage multiple pattern recognition receptors (PRRs) represent a promising strategy for shaping immune responses. Here we report the design and synthesis of covalently linked dual PRR agonists composed of a NOD1-selective ligand conjugated to agonists of TLR4, TL ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 5
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