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Št. zadetkov: 3
ǂThe ǂrole of plasmalemma vesicle-associated protein in pathological breakdown of blood-brain and blood-retinal barriers
Esmeralda K. Bosma, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen
Pregledni znanstveni članek
Oznake: biokemija;protein, povezan s plazmalemmo;krvno-možganska ovira;cerebralni edem;diabetični makularni edem;plasmalemma vesicle-associated protein;blood-brain barrier;blood-retinal barrier;cerebral edema;diabetic macular edema;
Breakdown of the blood–brain barrier (BBB) or inner blood–retinal barrier (BRB), induced by pathologically elevated levels of vascular endothelial growth factor (VEGF) or other mediators, can lead to vasogenic edema and significant clinical problems such as neuronal morbidity and mortality, or visio ...
Leto: 2018 Vir: Nacionalni inštitut za biologijo (NIB)
Quantitative assessment of the apical and basolateral membrane expression of VEGFR2 and NRP2 in VEGF-A-stimulated cultured human umbilical vein endothelial cells
Esmeralda K. Bosma, Shahan Darwesh, Jia Y. Zheng, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen
Izvirni znanstveni članek
Oznake: endotelijske celice;EGF;celična biologija;
Endothelial cells (ECs) form a precisely regulated polarized monolayer in capillary walls. Vascular endothelial growth factor-A (VEGF-A) induces endothelial hyperpermeability, and VEGF-A applied to the basolateral side, but not the apical side, has been shown to be a strong barrier disruptor in bloo ...
Leto: 2022 Vir: Nacionalni inštitut za biologijo (NIB)
Diferential roles of eNOS in late efects ofVEGF‑A on hyperpermeability in diferent types of endothelial cells
Esmeralda K. Bosma, Shahan Darwesh, Yasmin I. Habani, Maxime Cammeraat, Paola Serrano Martinez, Mathilda E. van Breest Smallenburg, JiaY. Zheng, Ilse M.C. Vogels, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen
Izvirni znanstveni članek
Oznake: endocytosis;RNAi;hyperpermeability;
Vascular endothelial growth factor (VEGF)-A induces endothelial hyperpermeability, but the molecular pathways remain incompletely understood. Endothelial nitric oxide synthase (eNOS) regulates acute efects of VEGF-A on permeability of endothelial cells (ECs), but it remains unknown whether and how e ...
Leto: 2023 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 3
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