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SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca2+oscillations in [beta] cell networks
Teresa Daraio, Lidija Križančić Bombek, Marko Gosak, Ismael Valladolid-Acebes, Maša Skelin, Essam Refai, Per-Olof Berggren, Kerstin Brismar, Marjan Rupnik, Christina Bark
Izvirni znanstveni članek
Oznake: insulin secretion;pre-diabetes;
SNAP-25 is a protein of the core SNARE complex mediating stimulus-dependent release of insulin from pancreatic [beta] cells. The protein exists as two alternatively spliced isoforms, SNAP-25a and SNAP-25b, differing in 9 out of 206 amino acids, yet their specific roles in pancreatic [beta] cells rem ...
Leto: 2017 Vir: Medicinska fakulteta (UM MF)
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