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Identification of a novel structural class of H[sub]v1 inhibitors by structure-based virtual screening
Martina Piga, Zoltán Varga, Ádám Fehér, Ferenc Papp, Eva Korpos Pintye-Gyuri, Kavya C. Bangera, Rok Frlan, Janez Ilaš, Jaka Dernovšek, Tihomir Tomašić, Nace Zidar
Izvirni znanstveni članek
Oznake: cancer;cells;inhibition;inhibitors;screening assays;
The human voltage-gated proton channel, hHv1, is highly expressed in various cell types including macrophages, B lymphocytes, microglia, sperm cells and also in various cancer cells. Overexpression of Hv1 has been shown to promote tumor formation by highly metastatic cancer cells, and has been assoc ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
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