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Št. zadetkov: 3
Brain tumour migration and invasion
Geoffrey J. Pilkington
Strokovni članek
Oznake:
Leto: 2002 Vir: dLib.si Digitalna knjižnica Slovenije
Apoptosis of human malignant glioma-derived cell cultures treated with clomipramine hydrochloride, as detected by annexin-V assay
Katharine A. Parker, Geoffrey J. Pilkington
Izvirni znanstveni članek
Oznake:
Background. Previous research in our laboratories has shown that Clomipramine Hydrochloride (CLOM), a tricyclic antidepressant in use for over thirty years,selectively kills neoplastic glial cells in vitro whilst leaving normal brain cells unaffected. The purpose of this study was to evaluate whethe ...
Leto: 2006 Vir: dLib.si Digitalna knjižnica Slovenije
The role of tricyclic drugs in selective triggering of mitochondrially-mediated apoptosis in neoplastic glia: a therapeutic option inmalignant glioma?
Geoffrey J. Pilkington, James Akinwunmi, Sabina Amar
Pregledni znanstveni članek
Oznake:
We have previously demonstrated that the tricyclic antidepressant, Clomipramine, exerts a concentration - dependent, tumor cell specific, pro-apoptotic effect on human glioma cells in vitro and than this effect is not mirrored in non-neoplastic human astrocytes. Moreover, the drug acts by triggering ...
Leto: 2006 Vir: dLib.si Digitalna knjižnica Slovenije
Št. zadetkov: 3
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