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Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of irinotecan and its main metabolites in human plasma and its application in a clinical pharmacokinetic study
Elena Marangon, Bianca Posocco, Elisa Mazzega, Giuseppe Toffoli
Izvirni znanstveni članek
Oznake: pharmacokinetics;pharmacodynamics;colorectal cancer;pharmacogenetics;
Irinotecan is currently used in several cancer regimens mainly in colorectal cancer (CRC). This drug has a narrow therapeutic range and treatment can lead to side effects, mainly neutropenia and diarrhea, frequently requiring discontinuing or lowering the drug dose. A wide inter-individual variabili ...
Leto: 2015 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 1
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