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Anthranilic acid inhibitors of undecaprenyl pyrophosphate synthase (UppS), an essential enzyme for bacterial cell wall biosynthesis
Marko Jukič, Kaja Rožman, Matej Sova, Hélene Barreteau, Stanislav Gobec
Izvirni znanstveni članek
Oznake: UppS;inhibitors;cell-wall;pharmacophore model;antibacterial agents;undecaprenyl pyrophosphate synthase;
We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia coli. UppS is an essential enzyme in the biosynthesis of bacterial cell wall. It catalyzes the condensation of farnesyl pyrophosphate (FPP) w ...
Leto: 2019 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 1
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