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Hyperthermia as a potential cornerstone of effective multimodality treatment with radiotherapy, cisplatin and PARP inhibitor in IDH1-mutated cancer cells
Mohammed Khurshed, Elia Prades-Sagarra, Sarah Al Saleh, Peter Sminia, Johanna W Wilmink, Remco J. Molenaar, Hans Crezee, Cornelis J. F. van Noorden
Izvirni znanstveni članek
Oznake: izocitrat dehidrogenaza;PARP;hipertemija;D‐2‐hidroksiglutarat;radioterapija;cisplatin;isocitrate dehydrogenase;hyperthermia;D‐2‐hydroxyglutarate;radiotherapy;
Mutations in the isocitrate dehydrogenase 1 (IDH1MUT) gene occur in various types of malignancies, including ~60% of chondrosarcomas, ~30% of intrahepatic cholangiocarcinomas and >80% of low-grade gliomas. IDH1MUT are causal in the development and progression of these types of cancer due to neomorph ...
Leto: 2022 Vir: Nacionalni inštitut za biologijo (NIB)
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