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Transcriptome study and identification of potential marker genes related to the stable expression of recombinant proteins in CHO clones
Uroš Jamnikar, Petra Nikolić, Aleš Belič, Marjanca Blas, Dominik Gaser, Andrej Francky, Holger Laux, Andrej Blejec, Špela Baebler, Kristina Gruden
Izvirni znanstveni članek
Oznake: CHO cell line;stable recombinant protein production;gene expression;RT-qPCR;DNA microarray;mMarker genes;
Background Chinese hamster ovary (CHO) cells have become the host of choice for the production of recombinant proteins, due to their capacity for correct protein folding, assembly, and posttranslational modifications. The most widely used system for recombinant proteins is the gene amplification pr ...
Leto: 2015 Vir: Nacionalni inštitut za biologijo (NIB)
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