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Št. zadetkov: 5
Spatial and temporal recruitment of the neurovascular unit during development of the mouse blood-retinal barrier
Anne-Eva van der Wijk, Ilse M.C. Vogels, Henk A. van Veen, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen
Izvirni znanstveni članek
Oznake: biokemija;endotelne celice;astrociti;periciti;endothelial cells;astrocytes;pericytes;retinal development;
The inner blood-retinal barrier (BRB) is made up by the neurovascular unit, consisting of endothelial cells, pericytes and glial cells. The BRB maintains homeostasis of the neural retina, but in pathological eye conditions the neurovascular unit is often disrupted, causing BRB loss. Here, we investi ...
Leto: 2018 Vir: Nacionalni inštitut za biologijo (NIB)
IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers
Marchien G. Dallinga, Bahar Yetkin-Arik, Richelle P. Kayser, Ilse M.C. Vogels, Patrycja Nowak-Sliwinska, Arjan W. Griffioen, Cornelis J. F. van Noorden, Ingeborg Klaassen, Reinier O. Schlingemann
Izvirni znanstveni članek
Oznake: biokemija;angiogeneza;endotelne celice;CD34;IGF2;Angiogenesis;tip cells;endothelial cells;cultured cells;endothelial growth factors;
Tip cells, the leading cells of angiogenic sprouts, were identified in cultures of human umbilical vein endothelial cells (HUVECs) by using CD34 as a marker. Here, we show that tip cells are also present in primary human microvascular endothelial cells (hMVECs), a more relevant endothelial cell type ...
Leto: 2018 Vir: Nacionalni inštitut za biologijo (NIB)
Diferential roles of eNOS in late efects ofVEGF‑A on hyperpermeability in diferent types of endothelial cells
Esmeralda K. Bosma, Shahan Darwesh, Yasmin I. Habani, Maxime Cammeraat, Paola Serrano Martinez, Mathilda E. van Breest Smallenburg, JiaY. Zheng, Ilse M.C. Vogels, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen
Izvirni znanstveni članek
Oznake: endocytosis;RNAi;hyperpermeability;
Vascular endothelial growth factor (VEGF)-A induces endothelial hyperpermeability, but the molecular pathways remain incompletely understood. Endothelial nitric oxide synthase (eNOS) regulates acute efects of VEGF-A on permeability of endothelial cells (ECs), but it remains unknown whether and how e ...
Leto: 2023 Vir: Nacionalni inštitut za biologijo (NIB)
Identification of proteins associated with clinical and pathological features of proliferative diabetic retinopathy in vitreous and fibrovascular membranes
Ingeborg Klaassen, Ewout W. de Vries, Ilse M.C. Vogels, Antoine H. C. van Kampen, Machteld I. Bosscha, David H. W. Steel, Cornelis J. F. van Noorden, Sarit Y Lesnik-Oberstein, Reinier O. Schlingemann
Izvirni znanstveni članek
Oznake: biokemija;medicinske znanosti;proteini;diabetična retinopatija;
Purpose To identify the protein profiles in vitreous associated with retinal fibrosis, angiogenesis, and neurite formation in epiretinal fibrovascular membranes (FVMs) in patients with proliferative diabetic retinopathy (PDR). Methods Vitreous samples of 5 non-diabetic control patients with vit ...
Leto: 2017 Vir: Nacionalni inštitut za biologijo (NIB)
Expression patterns of endothelial permeability pathways in the development of the blood-retinal barrier in mice
Anne-Eva van der Wijk, Joanna Wisniewska-Kruk, Ilse M.C. Vogels, Henk A. van Veen, Wing Fung Ip, Nicole N. van der Wel, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen
Izvirni znanstveni članek
Oznake: biokemija;celična membrana;plasmalemma;homeostaza;tight junctions;transcellular permeability;VEGF signaling;
Insight into the molecular and cellular processes in blood-retinal barrier (BRB) development, including the contribution of paracellular and transcellular pathways, is still incomplete but may help to understand the inverse process of BRB loss in pathologic eye conditions. In this comprehensive obse ...
Leto: 2019 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 5
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