Št. zadetkov: 12
Izvirni znanstveni članek
Oznake:
angiogenesis;endothelial tip cell;proliferative retinopathy;anti-angiogenesis therapy;retinal neovascularization;vascular sprouts;endothelial stalk cell;molecular mediators of angiogenesis;pericytes;
Endothelial tip cells are leading cells at the tips of vascular sprouts coordinating multiple processes during angiogenesis. In the developing retina, tip cells play a tightly controlled, timely role in angiogenesis. In contrast, excessive numbers of tip cells are a characteristic of the chaotic pat ...
Leto:
2013
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
biokemija;protein, povezan s plazmalemmo;krvno-možganska ovira;cerebralni edem;diabetični makularni edem;plasmalemma vesicle-associated protein;blood-brain barrier;blood-retinal barrier;cerebral edema;diabetic macular edema;
Breakdown of the blood–brain barrier (BBB) or inner blood–retinal barrier (BRB), induced by pathologically elevated levels of vascular endothelial growth factor (VEGF) or other mediators, can lead to vasogenic edema and significant clinical problems such as neuronal morbidity and mortality, or visio ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
endotelijske celice;EGF;celična biologija;
Endothelial cells (ECs) form a precisely regulated polarized monolayer in capillary walls. Vascular endothelial growth factor-A (VEGF-A) induces endothelial hyperpermeability, and VEGF-A applied to the basolateral side, but not the apical side, has been shown to be a strong barrier disruptor in bloo ...
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
biokemija;angiogeneza;celice;beljakovine;Angiogenesis;tip cells;IGF2;IGF binding proteins;endothelial cells;cultured cells;endothelial growth factors;
Purpose
We have previously identified insulin-like growth factor 2 (IGF2) and insulin-like growth factor 1 receptor (IGF1R) as essential proteins for tip cell maintenance and sprouting angiogenesis. In this study, we aim to identify other IGF family members involved in endothelial sprouting angioge ...
Leto:
2020
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
endothelial cells;angiogenesis;VEGFA;tip cells;SULF2;NRP2;HSPG;
During angiogenesis, vascular endothelial growth factor A (VEGFA) regulates endothelial cell (EC) survival, tip cell formation, and stalk cell proliferation via VEGF receptor 2 (VEGFR2). VEGFR2 can interact with VEGFR2 co-receptors such as heparan sulfate proteoglycans (HSPGs) and neuropilin 2 (NRP2 ...
Leto:
2021
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
biokemija;endotelne celice;astrociti;periciti;endothelial cells;astrocytes;pericytes;retinal development;
The inner blood-retinal barrier (BRB) is made up by the neurovascular unit, consisting of endothelial cells, pericytes and glial cells. The BRB maintains homeostasis of the neural retina, but in pathological eye conditions the neurovascular unit is often disrupted, causing BRB loss. Here, we investi ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
biokemija;angiogeneza;endotelne celice;CD34;IGF2;Angiogenesis;tip cells;endothelial cells;cultured cells;endothelial growth factors;
Tip cells, the leading cells of angiogenic sprouts, were identified in cultures of human umbilical vein endothelial cells (HUVECs) by using CD34 as a marker. Here, we show that tip cells are also present in primary human microvascular endothelial cells (hMVECs), a more relevant endothelial cell type ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Esmeralda K. Bosma,
Shahan Darwesh,
Yasmin I. Habani,
Maxime Cammeraat,
Paola Serrano Martinez,
Mathilda E. van Breest Smallenburg,
JiaY. Zheng,
Ilse M.C. Vogels,
Cornelis J. F. van Noorden,
Reinier O. Schlingemann,
Ingeborg Klaassen
Izvirni znanstveni članek
Oznake:
endocytosis;RNAi;hyperpermeability;
Vascular endothelial growth factor (VEGF)-A induces endothelial hyperpermeability, but the molecular
pathways remain incompletely understood. Endothelial nitric oxide synthase (eNOS) regulates acute
efects of VEGF-A on permeability of endothelial cells (ECs), but it remains unknown whether and how
e ...
Leto:
2023
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
biokemija;medicinske znanosti;proteini;diabetična retinopatija;
Purpose
To identify the protein profiles in vitreous associated with retinal fibrosis, angiogenesis, and neurite formation in epiretinal fibrovascular membranes (FVMs) in patients with proliferative diabetic retinopathy (PDR).
Methods
Vitreous samples of 5 non-diabetic control patients with vit ...
Leto:
2017
Vir:
Nacionalni inštitut za biologijo (NIB)
Bahar Yetkin-Arik,
Arnoud W. Kastelein,
Ingeborg Klaassen,
Charlotte H. J. R. Jansen,
Yani P. Latul,
Miloš Vittori,
Aydan Biri,
Korhan Kahraman,
Arjan W. Griffioen,
Frederic Amant,
Christianne A. R. Lok,
Reinier O. Schlingemann,
Cornelis J. F. van Noorden
Pregledni znanstveni članek
Oznake:
angiogeneza;antiangiogena terapija;tumorsko mikrookolje;ginekološki raki;angiogenesis;anti-angiogenic therapy;endothelial cells;endothelial cell metabolism;gynecological cancer;non-tip cells;tip cells;tumor microenvironment;vascular disrupting agents;
Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development of anti-angiogenesis therapy in gynecological cancers and improvement of its efficacy have been a major focus of fundamental and clinical research. However, sur ...
Leto:
2021
Vir:
Repozitorij Univerze v Ljubljani (RUL)