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Št. zadetkov: 2
N-hydroxy-N-propargylamide derivatives of ferulic acid
Oscar M. Bautista-Aguilera, José M. Alonso, Marco Catto, Isabel Iriepa, Damijan Knez, Stanislav Gobec, José Marco-Contelles
Izvirni znanstveni članek
Oznake: cholinesterases;ferulic acid;molecular modelling;monoamine oxidase;radical-scavenger;antioxidant;
Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical features of the disease at the biomolecular leve ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Polyfunctionalized α-phenyl-tert-butyl(benzyl)nitrones
Daniel Diez-Iriepa, Damijan Knez, Stanislav Gobec, Isabel Iriepa, Cristóbal de los Ríos, Isaac Bravo, Francisco López-Muñoz, José Marco-Contelles, Dimitra Hadjipavlou-Litina
Izvirni znanstveni članek
Oznake: antioksidanti;butirilholinesteraza;lovilci prostih radikalov;nevroprotekcija;α-fenil-terc-butil(benzil)nitroni;butyrylcholinesterase;free radical scavengers;neuroprotection;α-phenyl-tert-butyl(benzyl)nitrones;in vitro digestion;extractable and bound phenolics;
Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more tolerable and efficient therapy for stroke is ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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