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Synthesis and evaluation of spumigin analogues library with thrombin inhibitory activity
Aleš Žula, Izabela Będziak, Danijel Kikelj, Janez Ilaš
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Oznake: biokemija;morski proizvodi;naravni peptidi;inhibicija trombina;marine products;natural peptides;peptidomimetics;thrombin inhibition;
Spumigins are marine natural products derived from cyanobacteria Nodularia spumigena, which mimics the structure of the D-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S ...
Leto: 2018 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 1
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