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Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec
Izvirni znanstveni članek
Oznake: butyrylcholinesterase;inhibitor;probe;fluorescence;
Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer's disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal structure of previously described highly potent, revers ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
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