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Design, synthesis, and biological evaluation of 2-(benzylamino-2-hydroxyalkyl)isoindoline-1,3-diones derivatives as potential disease-modifying multifunctional anti-Alzheimer agents
Dawid Panek, Anna Więckowska, Anna Pasieka, Justyna Godyń, Jakub Jończyk, Marek Bajda, Damijan Knez, Stanislav Gobec, Barbara Malawska
Izvirni znanstveni članek
Oznake: isoindoline-1,3-dione derivatives;cholinesterase inhibitors;BACE-1 inhibitors;Abeta-aggregation;molecular modeling;multiple anti-Alzheimer's ligands;
The complex nature of Alzheimer's disease calls for multidirectional treatment. Consequently, the search for multi-target-directed ligands may lead to potential drug candidates. The aim of the present study is to seek multifunctional compounds with expected activity against disease-modifying and sym ...
Leto: 2018 Vir: Fakulteta za farmacijo (UL FFA)
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