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Št. zadetkov: 7
Proučevanje protitelesnega imunskega odziva pri bolnikih z različnim potekom COVID-19
Jan Slunečko, Tatjana Avšič-Županc, Miša Korva, Mojca Narat
Magistrsko delo
Oznake: virusi;koronavirusi;SARS-CoV-2;COVID-19;jakost imunskega odziva;resnost klinične slike;beljakovina bodice;podenota S1 beljakovine bodice;podenota S2 beljakovine bodice;nukleokapsidna beljakovina;receptor vezavna domena;imunski odziv;
Bolezen COVID-19 je posledica okužbe z virusom SARS-CoV-2 pri ljudeh. Bolezen poteka raznoliko: od poteka bolezni brez kliničnih znakov, do kritične oblike, ki lahko privede do smrti. Glavni klinični znaki pri COVID-19 so vročina, kašelj in utrujenost, neredko pa se pojavlja tudi oteženo dihanje in ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
MetaAll
Martin Bosilj, Alen Suljič, Samo Zakotnik, Jan Slunečko, Rok Kogoj, Miša Korva, Miša Korva
Izvirni znanstveni članek
Oznake: bioinformatics workflow;clinical metagenomics;long reads;pathogen detection;short PE reads;
Over the past decade, there have been many improvements in the field of metagenomics, including sequencing technologies, advances in bioinformatics and the development of reference databases, but a one-size-fits-all sequencing and bioinformatics pipeline does not yet seem achievable. In this study, ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
West Nile virus in Slovenia
Nataša Knap, Miša Korva, Vladimir Ivović, Katja Kalan, Mateja Jelovšek, Martin Sagadin, Samo Zakotnik, Katja Strašek, Jan Slunečko, Tatjana Avšič-Županc
Izvirni znanstveni članek
Oznake: West Nile virus;mosquitoes;Slovenia;
West Nile virus (WNV) is a flavivirus transmitted by mosquitoes. Birds are the reservoir for the virus; humans, horses and other mammals are dead-end hosts. Infections caused by WNV in humans can vary from asymptomatic infections to West Nile fever (WNF) or West Nile neuroinvasive disease (WNND). In ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Development and performance evaluation of a clinical metagenomics approach for identifying pathogens in the whole blood from patients with undifferentiated fever
Jan Slunečko, Rok Kogoj, Samo Zakotnik, Alen Suljič, Nataša Knap, Martin Bosilj, Franc Strle, Tatjana Avšič-Županc, Petra Bogovič, Petra Bogovič, Miša Korva, Miša Korva
Izvirni znanstveni članek
Oznake: mNGS;clinical metagenomics;molecular diagnostics;universal pathogen detection;enhanced RNA virus detection;
Introduction: Blood culture is the cornerstone of microbiological diagnostics for patients with acute undifferentiated fever and no obvious localization of infection; however, up to 50% of cases remain undiagnosed. Infections caused by arboviruses, fastidious or even uncultivable bacteria, or parasi ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins
Amare Aregay, Jan Slunečko, Miša Korva, Petra Bogovič, Katarina Resman Rus, Nataša Knap, Jana Beicht, Mareike Kubinski, Giulietta Saletti, Tatjana Avšič-Županc, Franc Strle
Izvirni znanstveni članek
Oznake: tick-borne encephalitis;vaccine;T-cells;
Tick-borne encephalitis virus (TBEV) vaccine breakthrough (VBT) infections are not uncommon in endemic areas. The clinical and immunological outcomes have been poorly investigated. We assessed the magnitude and specificity of virus-specific antibody and T cell responses after TBE in previously vacci ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity
Amare Aregay, Jan Slunečko, Petra Bogovič, Miša Korva, Katarina Resman Rus, Nataša Knap, Jana Beicht, Mareike Kubinski, Giulietta Saletti, Imke Steffen, Franc Strle, Tatjana Avšič-Županc
Izvirni znanstveni članek
Oznake: TBEV;tick-borne encephalitis (TBE);TBEV-specific T-cells;disease severity;outcome;
Tick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody and cell-mediated immune responses, shortly after infection, with clinical manifestations, severity and ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Emerging human pathogen
Miša Korva, Miša Korva, Petra Bogovič, Petra Bogovič, Nataša Knap, Rok Kogoj, Jan Slunečko, Samo Zakotnik, Alen Suljič, Katarina Resman Rus, Patricija Pozvek, Franc Strle, Tatjana Avšič-Županc, Miroslav Petrovec
Izvirni znanstveni članek
Oznake: 23S rRNA PCR;fever;metagenomics;patients;Spiroplasma ixodetis;tick-borne diseases;
Objectives: Febrile illness without clear localisation presents a significant diagnostic challenge due to non-specific symptoms and diverse aetiologies. Spiroplasma ixodetis, an emerging tick-associated pathogen previously linked mainly to congenital cataracts, has not been well characterised in adu ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 7
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