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Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell niches
Vashendriya V. V. Hira, Cornelis J. F. van Noorden, Hetty E. Carraway, Jaroslaw P. Maciejewski, Remco J. Molenaar
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Oznake: medicinske znanosti;levkemija;zdravljenje;terapevtske strategije;hematopoietic stem cell niche;hijacking;leukemic stem cells;bone marrow;therapy resistance;leukemia;
Acute myeloid leukemia and acute lymphoblastic leukemia cells hijack hematopoietic stem cell (HSC) niches in the bone marrow and become leukemic stem cells (LSCs) at the expense of normal HSCs. LSCs are quiescent and resistant to chemotherapy and can cause relapse of the disease. HSCs in niches are ...
Leto: 2017 Vir: Nacionalni inštitut za biologijo (NIB)
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