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Št. zadetkov: 3
Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i
Makoto Harada, Jonathan Adam, Marcela Covic, Jianhong Ge, Stefan Brandmaier, Caroline Muschet, Jerzy Adamski
Izvirni znanstveni članek
Oznake: anaplerosis;metabolic dysfunction-associated steatotic liver disease (MASLD);anti-inflammatory effects;metformin;pharmacometabolomics;SGLT2 inhibitors;TCA cycle;type 2 diabetes;
Background: Metformin and sodium-glucose-cotransporter-2 inhibitors (SGLT2i) are cornerstone therapies for managing hyperglycemia in diabetes. However, their detailed impacts on metabolic processes, particularly within the citric acid (TCA) cycle and its anaplerotic pathways, remain unclear. This st ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study
Sapna Sharma, Sapna Sharma, Qiuling Dong, Mark Haid, Jonathan Adam, Roberto Bizzotto, Juan J. Fernandez-Tajes, Jerzy Adamski
Izvirni znanstveni članek
Oznake: N-lactoylaminoacids;glycaemic traits;metabolomics;type 2 diabetes;
Aims/hypothesis: Type 2 diabetes is a chronic condition that is caused by hyperglycaemia. Our aim was to characterise the metabolomics to find their association with the glycaemic spectrum and find a causal relationship between metabolites and type 2 diabetes. Methods: As part of the Innovative Medi ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Metabolic effects of SGLT2i and metformin on 3-hydroxybutyric acid and lactate in db/db mice
Makoto Harada, Siyu Han, Mengya Shi, Jianhong Ge, Shixiang Yu, Jonathan Adam, Jerzy Adamski, Markus F. Scheerer, Susanne Neschen, Martin Hrabě de Angelis
Izvirni znanstveni članek
Oznake: branched-chain amino acids;diabetic ketoacidosis;lactic acidosis;metformin adds to SGLT2i;SGLT2i monotherapy;
Combining a Sodium-Glucose-Cotransporter-2-inhibitor (SGLT2i) with metformin is recommended for managing hyperglycemia in patients with type 2 diabetes (T2D) who have cardio-renal complications. Our study aimed to investigate the metabolic effects of SGLT2i and metformin, both individually and syner ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 3
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