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Št. zadetkov: 5
Expanding the reactive chemistry toolbox – warhead screening for covalent butyrylcholinesterase inhibitors
Anže Meden, Xavier Brazzolotto, Jose Dias, Jure Stojan, Damijan Knez, Stanislav Gobec
Izvirni znanstveni članek
Oznake: zaviralci holinesteraze;bojna glava;ireverzibilna inhibicija;butirilholinesteraza;karbamat;cholinesterase inhibitors;warhead;irreversible inhibition;butyrylcholinesterase;carbamate;
Many covalent inhibitors of butyryl- and acetylcholinesterase, typically featuring electrophilic carbamoyl, phosphonyl, and sulfonyl groups, were reported in the literature. In this study, we screened these and several other electrophilic moieties for covalent cholinesterase inhibition. The electrop ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
From tryptophan-based amides to tertiary amines
Anže Meden, Damijan Knez, Xavier Brazzolotto, Florian Nachon, Jose Dias, Jurij Svete, Jure Stojan, Uroš Grošelj, Stanislav Gobec
Izvirni znanstveni članek
Oznake: zaviralci holinesteraze;butirilholinesteraza;karbamat;psevdoireverzibilna inhibicija;cholinesterase inhibitors;Alzheimer's disease;butyrylcholinesterase;carbamate;pseudoirreversible inhibition;
Lead optimization of a series of tryptophan-based nanomolar butyrylcholinesterase (BChE) inhibitors led to tertiary amines as highly potent, achiral, sp (Chierrito et al., 2018) [3]-rich analogues with better synthetic accessibility and high selectivity over acetylcholinesterase (one to ten thousand ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
N-propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors
Urban Košak, Damijan Knez, Anja Pišlar, Selena Horvat, Simon Žakelj, Alexandre Igert, Jose Dias, Florian Nachon, Xavier Brazzolotto, Stanislav Gobec
Izvirni znanstveni članek
Oznake: butyrylcholinesterase;acetylcholinesterase;monoamine oxidase;monoamine oxidase A;monoamine oxidase B;enzyme inhibitors;pyrrolidines;
Butyrylcholinesterase (BChE) inhibitors are or could be used for the treatment of Alzheimer's disease, canine cognitive dysfunction, depression, multiple sclerosis, heroin abuse and metabolic disorders. Monoamine oxidase (MAO) inhibitors are or could be used for the treatment of depression, anxiety, ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
ǂThe ǂuse of computational intelligence techniques for mid-term electricity price forecasting
Miguel Fernandes da Fonseca, José Miguel Dias, Aleš Popovič
Magistrsko delo
Oznake: energetics;artificial intelligence;pricing;price;economic forecasting;research;analysis;
The use of computational intelligence techniques for mid-term electricity price forecasting
Leto: 2021 Vir: Ekonomska fakulteta (UL EF)
Exploring the cultural, managerial and organizational implications on mergers and acquisitions outcomes
Renato Lopes da Costa, João Miguel, Álvaro Dias, Leandro Pereira, José Santos
Izvirni znanstveni članek
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Background/Purpose: This work is focused on the variables that influence the outcomes of mergers and acquisitions, by learning from past mistakes, adopt better strategies and make wiser decisions to enhance the outcomes of their mergers and acquisitions. Using a qualitative approach, this research c ...
Leto: 2021 Vir: Fakulteta za organizacijske vede (UM FOV)
Št. zadetkov: 5
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