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Comparative electrophysiological characterization of ammodytoxin A, a β-neurotoxin from the nose-horned viper venom, and its enzymatically inactive mutant
Monika C. Žužek, Adrijan Ivanušec, Julija Herman, Jernej Šribar, Adrijana Leonardi, Robert Frangež, Igor Križaj
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Oznake: kačji strup;encimska aktivnost;snake venom;ammodytoxin;secreted phospholipase A2;anzymatic activity;cytochrome c oxidase;ß-neurotoxicity;
Presynaptic- or β-neurotoxicity of secreted phospholipases A2 (sPLA2) is a complex process. For full expression of β-neurotoxicity, the enzymatic activity of the toxin is essential. However, it has been shown that not all toxic effects of a β-neurotoxin depend on its enzymatic activity, for example, ...
Leto: 2024 Vir: Veterinarska fakulteta (UL VF)
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