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Št. zadetkov: 14
Magistrsko delo
Oznake: človeška tkiva;zakonodaja;laboratorijske raziskave;nadzor;
Pregled pravne podlage za izvajanje laboratorijskih raziskav na človeških tkivih in celicah in predlog za dopolnitev nacionalne zakonodaje
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Strokovni članek
Oznake: rak pljuč;sistemsko zdravljenje;smernice;
Rak pljuč je najbolj pogost rak (če upoštevamo nemelanocitni rak kože) in smrt zaradi raka pljuč je najbolj pogost vzrok smrti zaradi raka na svetu. V Sloveniji je po pogostosti na 4. Mestu in najbolj pogost vzrok smrti zaradi raka. Slabo preživetje bolnikov z rakom pljuč (5 letno srednje preživetje ...
Leto: 2017 Vir: Onkološki inštitut Ljubljana (OI)
Izvirni znanstveni članek
Oznake: maligni plevralni mezoteliom;ligand programirane celične smrti 1;programirana celična smrt 1;PD-L1;malignant pleural mesothelioma;programmed death-ligand 1;programmed cell death 1;
Background: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM). M ...
Leto: 2021 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake: podatki iz resničnega življenja;selperactinib;tarčna terapija;zaviralci tirozinskih kinaz;real-world data;selpercatinib;targeted therapy;tyrosine kinase inhibitor;
Introduction: Rearranged during transfection (RET) gene fusions are rare genetic drivers in non-small cell lung cancer (NSCLC). Selective RET-inhibitors such as selpercatinib have shown therapeutic activity in early clinical trials; however, their efficacy in the real-world setting is unknown. Metho ...
Leto: 2021 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake: onkološko zdravljenje;imunogenost;osnovno cepljenje mRNA;čvrsti tumorji;anticancer treatment;immunogenicity;mRNA-based vaccination;solid cancer;
Background: SARS-CoV-2 vaccination in cancer patients is crucial to prevent severe COVID-19 disease course. Methods: This study assessed immunogenicity of cancer patients on active treatment receiving mRNA-based SARS-CoV-2 vaccine by detection of anti-SARS-CoV-2 S1 IgG antibodies in serum, before, a ...
Leto: 2022 Vir: Onkološki inštitut Ljubljana (OI)
Izvirni znanstveni članek
Oznake: podatki iz resničnega življenja;capmatinib;tarčna terapija;real-world data;targeted therapy;
Background: Patients with non-small cell lung cancer (NSCLC) presenting with mesenchymal–epithelial transition (MET) exon 14 skipping mutation have an unfavorable prognosis with standard treatments. Capmatinib is a selective MET inhibitor, which showed promising efficacy in this patient population i ...
Leto: 2022 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake: maligni plevralni mezoteliom;receptorji za fibroblastne rastne dejavnike;azbest;imunoterapija;kemoterapija;genomska analiza;infigratinib;malignant pleural mesothelioma;fibroblast growth factor receptors;azbestos;immunotherapy;chemotherapy;genomic analysis;
Malignant pleural mesothelioma (MPM) is a devastating malignancy with limited therapeutic options. Fibroblast growth factor receptors (FGFR) and their ligands were shown to contribute to MPM aggressiveness and it was suggested that subgroups of MPM patients could benefit from FGFR-targeted inhibitor ...
Leto: 2019 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake: medicina;non-small cell lung cancer;EGFR exon 20 inhibitors;mobocertinib;real-world data;exon 20 insertion;
EGFR exon 20 (EGFR Ex20) insertion mutations in non-small cell lung cancer (NSCLC) are insensitive to traditional EGFR tyrosine kinase inhibitors (TKIs). Mobocertinib is the only approved TKI specifically designed to target EGFR Ex20. We performed an international, real-world safety and efficacy ana ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Št. zadetkov: 14
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