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Št. zadetkov: 5
ǂA ǂroadmap of therapeutic strategies for patients with multiple myeloma
Berend Snijder, Klara Kropivšek
Kratki znanstveni prispevek
Oznake: multiple myeloma;multiomics;deep learning;imaging;ex vivo drug screening;
Multiple myeloma is a rare and incurable cancer of plasma cells. To characterize this cancer, we developed an ex vivo drug screening method that combines imaging, deep learning and multiomics and applied it in an observational trial, uncovering new potential therapeutic strategies and underlying dis ...
Leto: 2023 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Postnatal dynamics of Zeb2 expression in rat brain
Klara Kropivšek, Jasmine Pickford, David A. Carter
Izvirni znanstveni članek
Oznake: transcription factor;RNA;untranslated region;miRNA;brain;rat;
ZEB2 is a transcription factor with established roles in neurogenesis but no defined function in postnatal brain despite extensive neuronal expression in telencephalic structures. Multiple, incompletely annotated transcripts derive from the Zeb2 locus; the purpose of the present study was to structu ...
Leto: 2014 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
ǂA ǂnovel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies
Roberto De Luca, Paul Kachel, Klara Kropivšek, Berend Snijder, Markus G. Manz, Dario Neri
Izvirni znanstveni članek
Oznake: antibodies;dual-cytokine-antibody;CD38;multiple myeloma;TRAIL, IL2;
A novel dual-cytokine–antibody fusion protein, consisting of an antibody directed against CD38 [a tumor-associated antigen mainly expressed on the surface of multiple myeloma (MM) cells], simultaneously fused to both tumor necrosis factor ligand superfamily member 10 (TRAIL) and interleukin-2 (IL2), ...
Leto: 2018 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Ex vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma
Klara Kropivšek, Paul Kachel, Sandra Goetze, Rebekka Wegmann, Yasmin Festl, Yannik Severin, Benjamin D. Hale, Julien Mena, Audrey Van Drogen, Nadja Dietliker
Izvirni znanstveni članek
Oznake: ultiple myeloma;precision medicine;ex-vivo;pharmacoscopy;proteotyping;oncology;hematology;microscopy;drug score;
Abstract Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM remains incurable and in need of guidelines to identify effective personalized treatments. Here, we survey the ex vivo dr ...
Leto: 2023 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
P856
Klara Kropivšek, Paul Kachel, Sandra Goetze, Rebekka Wegmann, Yannik Severin, Benjamin D. Hale, Yasmin Festl, Julien Mena, Audrey Van Drogen, Nadja Dietliker
Objavljeni povzetek znanstvenega prispevka na konferenci
Oznake: mutliple myeloma;hematology;precision medicine;microscopy;deep learning;phenotyping;oncology;proteotype;
Multiple myeloma (MM) is a cancer of plasma cells, defined by complex genetics and extensive intra- and inter-patient heterogeneity. Despite improved patient survival driven by a plethora of treatment options, the disease remains incurable. Molecularly-guided precision medicine to individualize t ...
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 5
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