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Methylation of selenocysteine catalysed by thiopurine S-methyltransferase
Dunja Urbančič, Anita Kotar, Alenka Šmid, Marko Jukič, Stanislav Gobec, Lars Martensson, Janez Plavec, Irena Mlinarič-Raščan
Izvirni znanstveni članek
Oznake: Binding analysis;enzymatic methylation;NMR spectroscopy;S-adenosylmethionine;selenocysteine thiopurine;S-methyltransferase;
Background Methylation driven by thiopurine S-methylatransferase (TPMT) is crucial for deactivation of cytostatic and immunosuppressant thiopurines. Despite its remarkable integration into clinical practice, the endogenous function of TPMT is unknown. Methods To address the role of TPMT in methylati ...
Leto: 2019 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 1
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