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Št. zadetkov: 5
On the quaternary structure of humanD-3-phosphoglycerate dehydrogenase
Daniele Riva, Marco Orlando, Valentina Rabattoni, Loredano Pollegioni
Izvirni znanstveni članek
Oznake: L-serine;oligomeric structure;phosphorylated pathway;serine deficiency disorders;serinosome;
D‐3‐phosphoglycerate dehydrogenase (PHGDH) catalyzes the NAD+‐dependent conversion of D‐3‐phospho‐glycerate to 3‐phosphohydroxypyruvate, the first step in the phosphorylated pathway for L‐serine (L‐Ser) biosynthesis. L‐Ser plays different relevant metabolic roles in eukaryotic cells: alterations in ...
Leto: 2024 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
ǂAn ǂefficient protein evolution workflow for the improvement of bacterial PET hydrolyzing enzymes
Valentina Pirillo, Marco Orlando, Davide Tessaro, Loredano Pollegioni, Gianluca Molla
Izvirni znanstveni članek
Oznake: biocatalysis;biodegradation;protein engineering;polyethylene terephthalate;hydrolases;
Enzymatic degradation is a promising green approach to bioremediation and recycling of the polymer poly(ethylene terephthalate) (PET). In the past few years, several PET-hydrolysing enzymes (PHEs) have been discovered, and new variants have been evolved by protein engineering. Here, we report on a s ...
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Efficient polyethylene terephthalate degradation at moderate temperature
Valentina Pirillo, Marco Orlando, Caren Battaglia, Loredano Pollegioni, Gianluca Molla
Izvirni znanstveni članek
Oznake: green technology;improved LCC;polyethylene terephthalate;biodegradation;rational design;
Enzymatic degradation of poly(ethylene terephthalate) (PET) is becoming a reality because of the identification of novel PET‐hydrolysing enzymes (PHEs) and the engineering of evolved enzyme variants. Here, improved variants of leaf‐branch compost cutinase (LCC), a thermostable enzyme isolated by a m ...
Leto: 2023 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Biochemical and cellular studies of three human 3-phosphoglycerate dehydrogenase variants responsible for pathological reduced L-serine levels
Giulia Murtas, Elena Zerbini, Valentina Rabattoni, Zoraide Motta, Laura Caldinelli, Marco Orlando, Francesco Marchesani, Barbara Campanini, Silvia Sacchi, Loredano Pollegioni
Izvirni znanstveni članek
Oznake: L-serine;serinosome;phosphoglycerate dehydrogenase;mutants;aggregation;neurological impairment;
In the brain, the non‐essential amino acid L‐serine is produced through the phosphorylated pathway (PP) starting from the glycolytic intermediate 3‐phosphoglycerate: among the different roles played by this amino acid, it can be converted into D‐serine and glycine, the two main co‐agonists of NMDA r ...
Leto: 2024 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Valorization of organic waste through black soldier fly
Daniele Bruno, Marco Orlando, Edoardo Testa, Marco Carnevale Miino, Giulia Pesaro, Matteo Miceli, Loredano Pollegioni, Vincenzina Barbera, Elisa Fasoli, Lorenza Draghi
Izvirni znanstveni članek
Oznake: waste management;insect bioconversion;biomass valorization;protein-based films;circular bioeconomy;
The transition from a linear to a circular production system involves transforming waste into valuable resources. Insect-mediated bioconversion, particularly using black soldier fly (BSF) larvae, can offer a promising opportunity to convert the organic fraction of municipal solid waste (OFMSW) into ...
Leto: 2025 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 5
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