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Cathepsin K cleavage of SDF-1[alpha] inhibits its chemotactic activity towards glioblastoma stem-like cells
Vashendriya V. V. Hira, Urška Verbovšek, Barbara Breznik, Matic Srdič, Marko Novinec, Hala Kakar, Jill Wormer, Britt van der Swaan, Brigita Lenarčič, Luiz Juliano, Shwetal Mehta, Cornelis J. F. van Noorden, Tamara Lah Turnšek
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Oznake: glioma stem-like cells;niche;stromal derived factor-[alpha];cathepsin K;
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor patient survival that is at least partly caused by malignant and therapy-resistant glioma stem-like cells (GSLCs) that are protected in GSLC niches. Previously, we have shown that the chemo-attractant stromal-derived factor-1α ( ...
Leto: 2017 Vir: Nacionalni inštitut za biologijo (NIB)
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