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Št. zadetkov: 3
IGF-binding proteins 3 and 4 are regulators of sprouting angiogenesis
Marchien G. Dallinga, Yasmin I. Habani, Richelle P. Kayser, Cornelis J. F. van Noorden, Ingeborg Klaassen, Reinier O. Schlingemann
Izvirni znanstveni članek
Oznake: biokemija;angiogeneza;celice;beljakovine;Angiogenesis;tip cells;IGF2;IGF binding proteins;endothelial cells;cultured cells;endothelial growth factors;
Purpose We have previously identified insulin-like growth factor 2 (IGF2) and insulin-like growth factor 1 receptor (IGF1R) as essential proteins for tip cell maintenance and sprouting angiogenesis. In this study, we aim to identify other IGF family members involved in endothelial sprouting angioge ...
Leto: 2020 Vir: Nacionalni inštitut za biologijo (NIB)
ǂThe ǂrole of heparan sulfate and neuropilin 2 in VEGFA signaling in human endothelial tip cells and non-tip cells during angiogenesis in vitro
Marchien G. Dallinga, Yasmin I. Habani, Alinda W. M. Schimmel, Geesje M. Dallinga-Thie, Cornelis J. F. van Noorden, Ingeborg Klaassen, Reinier O. Schlingemann
Izvirni znanstveni članek
Oznake: endothelial cells;angiogenesis;VEGFA;tip cells;SULF2;NRP2;HSPG;
During angiogenesis, vascular endothelial growth factor A (VEGFA) regulates endothelial cell (EC) survival, tip cell formation, and stalk cell proliferation via VEGF receptor 2 (VEGFR2). VEGFR2 can interact with VEGFR2 co-receptors such as heparan sulfate proteoglycans (HSPGs) and neuropilin 2 (NRP2 ...
Leto: 2021 Vir: Nacionalni inštitut za biologijo (NIB)
IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers
Marchien G. Dallinga, Bahar Yetkin-Arik, Richelle P. Kayser, Ilse M.C. Vogels, Patrycja Nowak-Sliwinska, Arjan W. Griffioen, Cornelis J. F. van Noorden, Ingeborg Klaassen, Reinier O. Schlingemann
Izvirni znanstveni članek
Oznake: biokemija;angiogeneza;endotelne celice;CD34;IGF2;Angiogenesis;tip cells;endothelial cells;cultured cells;endothelial growth factors;
Tip cells, the leading cells of angiogenic sprouts, were identified in cultures of human umbilical vein endothelial cells (HUVECs) by using CD34 as a marker. Here, we show that tip cells are also present in primary human microvascular endothelial cells (hMVECs), a more relevant endothelial cell type ...
Leto: 2018 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 3
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