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Št. zadetkov: 2
Role of TDP-43 aggregation in neurodegeneration
Lucía Cragnaz, Marco Baralle
Doktorska disertacija
Oznake: TDP-43/TBPH;aggregation;Drosophila melanogaster;ALS;
TDP-43 inclusions are important histopathological features of various neurodegenerative disorders, including Amyotrophic Lateral Sclerosis. However, the relation of these inclusions with the pathogenesis of the disease is still unclear. Various hypotheses have been proposed. For instance, it was sug ...
Leto: 2016 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Structural and functional determinants of TDP-43 aggregation
Sanja Škaro, Marco Baralle
Doktorska disertacija
Oznake: TDP-43 structural determinants;hybrid peptides;protein-protein interactions;intramolecular interaction;cation-π interaction;Drosophila orthologues.;
TDP-43 (TAR DNA-binding protein) is an hnRNP that was identified as the main component of the brain inclusions characteristically found in patients suffering of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. As an hnRNP protein, TDP-43 fulfills diverse roles in mRNA metabolism, ...
Leto: 2019 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 2
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