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Synthesis and cholinesterase inhibitory activity of selected indole-based compounds
Marija Gršič, Anže Meden, Damijan Knez, Marko Jukič, Jurij Svete, Stanislav Gobec, Uroš Grošelj
Izvirni znanstveni članek
Oznake: indole derivatives;tryptophan derivatives;amidations;cholinesterase (ChE) inhibitors;1,1’-Carbonyldiimidazole (CDI);rearrangements;catalytic hydrogenation;
Synthesis and anticholinesterase activity of 18 previously unpublished indole- and tryptophan-derived compounds are disclosed. These compounds containing an indole structural unit exhibit selective submicromolar inhibition of human butyrylcholinesterase (hBChE). The structures of the newly synthesiz ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 1
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