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Št. zadetkov: 2
Smart cages, better welfare
Rohish Kaura, Dragan Hrnčić, Amela Dervišević, Veronika Borbelyova, Özge Selin Çevik, Marija Heffer, Maša Čater
Pregledni znanstveni članek
Oznake: laboratory animals;automated behaviour tracking;refinement, continuous data collection;stress;
High welfare standards for animals used in research is as much an ethical issue as it is a cornerstone of high-quality science. Researchers can improve both animal welfare and data reliability by implementing strategies that reduce stress in experimental animals. One modern and effective approach is ...
Leto: 2025 Vir: Biotehniška fakulteta (UL BF)
Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis
Tinkara Kreft, Kaja Blagotinšek Cokan, Cene Skubic, Tadeja Režen, Martina Perše, Karmen Wechtersbach, Nika Kojc, Jera Jeruc, Željko Debeljak, Marija Heffer, Madlen Matz-Soja, Damjana Rozman, Damjana Rozman
Izvirni znanstveni članek
Oznake: CYP51;cholesterol metabolism;crystals;cytochrome P450;lanosterol 14α-demethylase;lipid droplets;liver;mouse model;sterol;
Lanosterol 14α-demethylase (CYP51), a key enzyme in cholesterol synthesis, is essential for normal liver function. Reduced CYP51 activity leads to metabolism-associated liver disease and ultimately hepatocellular carcinoma, yet the hepatocellular processes most affected and their crosstalk with othe ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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